0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - Consolidated Balance Sheets link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - Consolidated Balance Sheets (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - Consolidated Statements of Operations and Comprehensive Income (Loss) link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - Consolidated Statements of Stockholders' Equity link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - Consolidated Statements of Cash Flows link:presentationLink link:calculationLink link:definitionLink 9952156 - Disclosure - Organization and Significant Accounting Policies link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Collaboration and License Agreements link:presentationLink link:calculationLink link:definitionLink 9952158 - 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Disclosure - Financing Agreement link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Net Income (Loss) Per Share link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Segment Information link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Organization and Significant Accounting Policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Organization and Significant Accounting Policies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Collaboration and License Agreements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Balance Sheet Accounts (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Investments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Intangible Assets (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Stockholders' Equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Leases (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Stock-Based Compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Fair Value Measurements (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - Disclosure - Liability Related to the Sale of Future Royalties (Tables) link:presentationLink link:calculationLink link:definitionLink 9955522 - Disclosure - Financing Agreement (Tables) link:presentationLink link:calculationLink link:definitionLink 9955523 - Disclosure - Net Income (Loss) Per Share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955524 - Disclosure - Segment Information (Tables) link:presentationLink link:calculationLink link:definitionLink 9955525 - Disclosure - Organization and Significant Accounting Policies - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955526 - Disclosure - Collaboration and License Agreements - Schedule of Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955527 - Disclosure - Collaboration and License Agreements - Schedule of Receivables and Contract Liabilities (Details) link:presentationLink link:calculationLink link:definitionLink 9955528 - Disclosure - Collaboration and License Agreements - Schedule of Deferred Revenue (Details) link:presentationLink link:calculationLink link:definitionLink 9955529 - Disclosure - Collaboration and License Agreements - GlaxoSmithKline Intellectual Property (No. 3) Limited (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Collaboration and License Agreements - Takeda Pharmaceutical Company Limited (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Collaboration and License Agreements - Amgen, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Collaboration and License Agreements - Sarepta Therapeutics, Inc. (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Collaboration and License Agreements - Novartis Pharma AG (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Collaboration and License Agreements - Visirna Therapeutics Inc. (“Visirna”) and Genzyme Corporation (“Sanofi”) (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Balance Sheet Accounts - Schedule of Property, Plant and Equipment (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Balance Sheet Accounts - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Balance Sheet Accounts - Schedule of Accrued Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Investments - Schedule of Short-Term and Long-Term Investments and Marketable Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Investments - Schedule of Contract Maturity of Available for Sale Securities (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Intangible Assets - Schedule of Intangible Assets (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Intangible Assets - Schedule of Expected Future Amortization (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Stockholders' Equity - Schedule of Shares of Common Stock and Preferred Stock (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Stockholders' Equity - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Commitments and Contingencies (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Leases - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Leases - Schedule of Lease Assets and Liabilities and Lease Cost (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Leases - Schedule of Maturities of Operating Lease Liabilities on an Undiscounted Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Leases - Schedule of Maturities of Operating Lease Liabilities on an Undiscounted Basis (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Leases - Schedule of Cash Flow and Other Information Related to Leases (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Stock-Based Compensation - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Stock-Based Compensation - Schedule of Awards Outstanding (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Stock-Based Compensation - Schedule of Stock-Based Compensation Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Stock-Based Compensation - Schedule of Stock Option Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Stock-Based Compensation - Schedule of Share Activity Related to RSUs (Details) link:presentationLink link:calculationLink link:definitionLink 9955554 - Disclosure - Fair Value Measurements (Details) link:presentationLink link:calculationLink link:definitionLink 9955555 - Disclosure - Liability Related to the Sale of Future Royalties - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955556 - Disclosure - Liability Related to the Sale of Future Royalties - Schedule of Liability Related to the Sale of Future Royalties (Details) link:presentationLink link:calculationLink link:definitionLink 9955557 - Disclosure - Financing Agreement - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955558 - Disclosure - Financing Agreement - Schedule of Outstanding Balance of Credit Facility (Details) link:presentationLink link:calculationLink link:definitionLink 9955559 - Disclosure - Financing Agreement - Schedule of Total Interest Expense Recognized (Details) link:presentationLink link:calculationLink link:definitionLink 9955560 - Disclosure - Financing Agreement - Schedule of Principal Repayment Related to Credit Facility (Details) link:presentationLink link:calculationLink link:definitionLink 9955561 - Disclosure - Net Income (Loss) Per Share - Schedule of Computation of Basic and Diluted Net (Loss) Income Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955562 - Disclosure - Net Income (Loss) Per Share - Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955563 - Disclosure - Segment Information - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955564 - Disclosure - Segment Information - Research and Development and Selling, General and Administrative Expenses (Details) link:presentationLink link:calculationLink link:definitionLink 9955565 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink