<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2024 Workiva-->
<!--r:5b7d65f2-cbf1-4ad3-8ce4-dc8e7e64d980,g:f34ae38b-cb60-4701-b3c6-4544f5978a5b-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://xbrl.sec.gov/ecd/role/PvpDisclosure" xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#PvpDisclosure"/>
  <link:presentationLink xlink:role="http://xbrl.sec.gov/ecd/role/PvpDisclosure" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_ecd_AllAdjToCompMember" xlink:href="https://xbrl.sec.gov/ecd/2023/ecd-2023.xsd#ecd_AllAdjToCompMember"/>
    <link:loc xlink:type="locator" xlink:label="loc_arwr_EquityAwardsReportedValueMember" xlink:href="arwr-20240126.xsd#arwr_EquityAwardsReportedValueMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="loc_arwr_EquityAwardsReportedValueMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <link:loc xlink:type="locator" xlink:label="loc_arwr_EquityAwardsGrantedDuringTheYearUnvestedMember" xlink:href="arwr-20240126.xsd#arwr_EquityAwardsGrantedDuringTheYearUnvestedMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="loc_arwr_EquityAwardsGrantedDuringTheYearUnvestedMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <link:loc xlink:type="locator" xlink:label="loc_arwr_EquityAwardsGrantedDuringTheYearVestedMember" xlink:href="arwr-20240126.xsd#arwr_EquityAwardsGrantedDuringTheYearVestedMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="loc_arwr_EquityAwardsGrantedDuringTheYearVestedMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <link:loc xlink:type="locator" xlink:label="loc_arwr_EquityAwardsGrantedInPriorYearsUnvestedMember" xlink:href="arwr-20240126.xsd#arwr_EquityAwardsGrantedInPriorYearsUnvestedMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="loc_arwr_EquityAwardsGrantedInPriorYearsUnvestedMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/label"/>
    <link:loc xlink:type="locator" xlink:label="loc_arwr_EquityAwardsGrantedInPriorYearsVestedMember" xlink:href="arwr-20240126.xsd#arwr_EquityAwardsGrantedInPriorYearsVestedMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_ecd_AllAdjToCompMember" xlink:to="loc_arwr_EquityAwardsGrantedInPriorYearsVestedMember" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/label"/>
  </link:presentationLink>
</link:linkbase>
