0001628280-22-021068 | 10-Q | XBRL Viewer | Arrowhead Pharmaceuticals INC

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Cover - shares	9 Months Ended
Cover - shares	Jun. 30, 2022	Jul. 28, 2022
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Jun. 30, 2022
Document Transition Report	false
Entity File Number	001-38042
Entity Registrant Name	ARROWHEAD PHARMACEUTICALS, INC.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	46-0408024
Entity Address, Address Line One	177 E. Colorado Blvd
Entity Address, Address Line Two	Suite 700
Entity Address, City or Town	Pasadena
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	91105
City Area Code	626
Local Phone Number	304-3400
Title of 12(b) Security	Common Stock, par value $0.001 per share
Trading Symbol	ARWR
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Large Accelerated Filer
Entity Emerging Growth Company	false
Entity Small Business	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		105,848,963
Entity Central Index Key	0000879407
Current Fiscal Year End Date	--09-30
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q3
Amendment Flag	false

Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2022	Sep. 30, 2021
CURRENT ASSETS
Cash and cash equivalents	$ 139,439	$ 184,434
Accounts receivable	239	10,255
Prepaid expenses	6,761	4,362
Other current assets	8,892	2,191
Marketable securities	0	126,728
Short term investments	277,057	56,627
TOTAL CURRENT ASSETS	432,388	384,597
Property and equipment, net	71,904	48,675
Intangible assets, net	12,387	13,663
Long term investments	165,920	245,595
Right-of-use assets	68,908	17,346
Other assets	275	272
TOTAL ASSETS	751,782	710,148
CURRENT LIABILITIES
Accounts payable	5,894	9,457
Accrued expenses	32,499	14,001
Accrued payroll and benefits	2,648	9,773
Lease liabilities	2,883	2,250
Deferred revenue	84,288	111,055
TOTAL CURRENT LIABILITIES	128,212	146,536
LONG-TERM LIABILITIES
Lease liabilities, net of current portion	78,231	23,295
Deferred revenue, net of current portion	71,162	131,495
TOTAL LONG-TERM LIABILITIES	149,393	154,790
Commitments and contingencies (Note 7)
Arrowhead Pharmaceuticals, Inc. stockholders’ equity:
Common stock, $0.001 par value; 145,000 shares authorized; 105,795 and 104,327 shares issued and outstanding as of June 30, 2022 and September 30, 2021, respectively	198	197
Additional paid-in capital	1,189,113	1,053,386
Accumulated other comprehensive loss	(140)	(69)
Accumulated deficit	(735,244)	(644,692)
TOTAL ARROWHEAD PHARMACEUTICALS INC. STOCKHOLDERS' EQUITY	453,927	408,822
Noncontrolling Interest	20,250	0
TOTAL STOCKHOLDERS’ EQUITY	474,177	408,822
TOTAL LIABILITIES, NONCONTROLLING INTEREST AND STOCKHOLDERS’ EQUITY	$ 751,782	$ 710,148

Consolidated Balance Sheets (Parenthetical) - $ / shares	Jun. 30, 2022	Sep. 30, 2021
Statement of Financial Position [Abstract]
Common stock, par value (in dollars per share)	$ 0.001	$ 0.001
Common stock, shares authorized (in shares)	145,000,000	145,000,000
Common stock, shares issued (in shares)	105,795,000	104,327,000
Common stock, shares outstanding (in shares)	105,795,456	104,327,000

Consolidated Statements of Operations and Comprehensive Income (Loss) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Income Statement [Abstract]
REVENUE	$ 32,412	$ 45,891	$ 211,656	$ 100,004
OPERATING EXPENSES
Research and development	72,180	59,325	213,930	140,576
General and administrative expenses	33,141	18,434	92,403	43,581
TOTAL OPERATING EXPENSES	105,321	77,759	306,333	184,157
OPERATING INCOME (LOSS)	(72,909)	(31,868)	(94,677)	(84,153)
OTHER INCOME
Interest income, net	1,240	1,280	3,450	4,972
Other income (expense)	(377)	664	675	1,707
TOTAL OTHER INCOME	863	1,944	4,125	6,679
INCOME (LOSS) BEFORE INCOME TAXES	(72,046)	(29,924)	(90,552)	(77,474)
Provision for income taxes	0	0	0	0
NET INCOME (LOSS)	$ (72,046)	$ (29,924)	$ (90,552)	$ (77,474)
NET INCOME (LOSS) PER SHARE - BASIC (in dollars per share)	$ (0.68)	$ (0.29)	$ (0.86)	$ (0.75)
NET INCOME (LOSS) PER SHARE - DILUTED (in dollars per share)	$ (0.68)	$ (0.29)	$ (0.86)	$ (0.75)
Weighted average shares outstanding - basic (in shares)	105,753	104,099	105,273	103,569
Weighted average shares outstanding - diluted (in shares)	105,753	104,099	105,273	103,569
OTHER COMPREHENSIVE INCOME (LOSS), NET OF TAX:
Foreign currency translation adjustments	$ (33)	$ (40)	$ (71)	$ 44
COMPREHENSIVE INCOME (LOSS)	$ (72,079)	$ (29,964)	$ (90,623)	$ (77,430)

Consolidated Statements of Stockholders’ Equity and Noncontrolling Interest - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit	Noncontrollling Interest
Beginning balance at Sep. 30, 2020	$ 461,779	$ 195	$ 965,410	$ 18	$ (503,844)	$ 0
Beginning balance (in shares) at Sep. 30, 2020		102,376,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-based compensation	42,051		42,051
Exercise of stock options	10,490	$ 1	10,489
Exercise of stock options (in shares)		981,000
Common stock - restricted stock units vesting	0	$ 1	(1)
Common stock - restricted stock units vesting (in shares)		852,000
Foreign currency translation adjustments	44			44
Net income (loss)	(77,474)				(77,474)
Ending balance at Jun. 30, 2021	436,890	$ 197	1,017,949	62	(581,318)	0
Ending balance (in shares) at Jun. 30, 2021		104,209,000
Beginning balance at Mar. 31, 2021	445,549	$ 196	996,645	102	(551,394)	0
Beginning balance (in shares) at Mar. 31, 2021		104,020,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-based compensation	18,549		18,549
Exercise of stock options	2,756	$ 1	2,755
Exercise of stock options (in shares)		161,000
Common stock - restricted stock units vesting (in shares)		28,000
Foreign currency translation adjustments	(40)			(40)
Net income (loss)	(29,924)				(29,924)
Ending balance at Jun. 30, 2021	436,890	$ 197	1,017,949	62	(581,318)	0
Ending balance (in shares) at Jun. 30, 2021		104,209,000
Beginning balance at Sep. 30, 2021	408,822	$ 197	1,053,386	(69)	(644,692)	0
Beginning balance (in shares) at Sep. 30, 2021		104,327,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-based compensation	91,697		91,697
Exercise of stock options	$ 4,281		4,281
Exercise of stock options (in shares)	506,596	497,000
Common stock - restricted stock units vesting	$ 0	$ 1	(1)
Common stock - restricted stock units vesting (in shares)		971,000
Foreign currency translation adjustments	(71)			(71)
Interest in joint venture	60,000		39,750			20,250
Net income (loss)	(90,552)				(90,552)
Ending balance at Jun. 30, 2022	474,177	$ 198	1,189,113	(140)	(735,244)	20,250
Ending balance (in shares) at Jun. 30, 2022		105,795,000
Beginning balance at Mar. 31, 2022	452,266	$ 198	1,115,373	(107)	(663,198)	0
Beginning balance (in shares) at Mar. 31, 2022		105,702,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-based compensation	33,391		33,391
Exercise of stock options	599		599
Exercise of stock options (in shares)		53,000
Common stock - restricted stock units vesting	0
Common stock - restricted stock units vesting (in shares)		40,000
Foreign currency translation adjustments	(33)			(33)
Interest in joint venture	60,000		39,750			20,250
Net income (loss)	(72,046)				(72,046)
Ending balance at Jun. 30, 2022	$ 474,177	$ 198	$ 1,189,113	$ (140)	$ (735,244)	$ 20,250
Ending balance (in shares) at Jun. 30, 2022		105,795,000

Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income (loss)	$ (90,552)	$ (77,474)
Stock-based compensation	91,697	42,051
Depreciation and amortization	7,761	5,763
Unrealized (gains) losses on marketable securities	5,755	(1,387)
Amortization/(accretion) of note premiums/discounts	2,013	142
Changes in operating assets and liabilities:
Accounts receivable	10,016	174
Prepaid expenses and other current assets	(8,876)	(2,895)
Deferred revenue	(87,100)	211,392
Accounts payable	(3,563)	3,208
Accrued expenses	1,713	13,682
Other	3,672	685
NET CASH PROVIDED BY (USED IN) OPERATING ACTIVITIES	(67,464)	195,341
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of property and equipment	(20,066)	(15,368)
Purchases of investments	(223,391)	(95,195)
Proceeds from sale of investments	201,595	87,130
NET CASH PROVIDED BY (USED IN) INVESTING ACTIVITIES	(41,862)	(23,433)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from the exercises of stock options	4,331	10,490
Proceeds from investment in joint venture	60,000	0
NET CASH PROVIDED BY FINANCING ACTIVITIES	64,331	10,490
NET INCREASE (DECREASE) IN CASH	(44,995)	182,398
CASH AND CASH EQUIVALENTS AT BEGINNING OF PERIOD	184,434	143,583
CASH AND CASH EQUIVALENTS AT END OF PERIOD	$ 139,439	$ 325,981

Organization and Significant Accounting Policies	9 Months Ended
Organization and Significant Accounting Policies	Jun. 30, 2022
Accounting Policies [Abstract]
Organization and Significant Accounting Policies	ORGANIZATION AND SIGNIFICANT ACCOUNTING POLICIES Nature of Business and Recent Developments Arrowhead Pharmaceuticals, Inc. develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference (“RNAi”) is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. The Company’s pipeline includes ARO-APOC3 for hypertriglyceridemia, ARO-ANG3 for dyslipidemia, ARO-ENaC2 for cystic fibrosis, ARO-DUX4 for facioscapulohumeral muscular dystrophy, ARO-COV for the coronavirus that causes COVID-19 and other possible future pulmonary-borne pathogens, ARO-C3 for complement mediated diseases, ARO-RAGE and ARO-MUC5AC for various muco-obstructive or inflammatory pulmonary conditions and ARO-MMP7 for idiopathic pulmonary fibrosis. ARO-HSD for liver disease was out-licensed to Glaxosmithkline Intellectual Property (No. 3) Limited (“GSK”) in November 2021. ARO-XDH is being developed for uncontrolled gout under a collaboration agreement with Horizon Therapeutics Ireland DAC (“Horizon”). JNJ-75220795 (ARO-JNJ1) is being developed by Janssen as a potential treatment for patients with non-alcoholic steatohepatitis (NASH). ARO-AAT for liver disease associated with alpha-1 antitrypsin deficiency (“AATD”) was out-licensed to Takeda Pharmaceuticals U.S.A., Inc. (“Takeda”) in October 2020. JNJ-3989 (formerly referred to as ARO-HBV) for chronic hepatitis B virus was out-licensed to Janssen in October 2018. Olpasiran (formerly referred to as AMG 890 or ARO-LPA) for cardiovascular disease was out-licensed to Amgen Inc. (“Amgen”) in 2016. While the Company believes that initial ARO-HIF2 Phase 1 clinical data provides proof of concept for the ability to deliver siRNA to RCC tumors, the Company has decided not to pursue further clinical development of ARO-HIF2 based on a number of factors including the evolving competitive landscape for HIF2 inhibitors. Arrowhead operates lab facilities in Madison, Wisconsin and San Diego, California, where the Company’s research and development activities, including the development of RNAi therapeutics, take place. The Company’s principal executive offices are located in Pasadena, California. During the first three quarters of fiscal 2022, the Company continued to develop and advance its pipeline and partnered candidates and expanded its facilities to support the Company’s growing pipeline. Several key recent developments include: i)dosed the first patients in its PALISADE study, a phase 3 clinical study to evaluate the safety and efficacy of ARO-APOC3 in adults with familial chylomicronemia syndrome (FCS); ii)entered into an exclusive license agreement with GSK for ARO-HSD; iii)Janssen presented clinical data from REEF-1, a Phase 2b study of different combination regimens, including JNJ-73763989 (JNJ-3989), formerly called ARO-HBV, and/or JNJ-56136379 (JNJ-6379), and a nucleos(t)ide analog (NA) for the treatment of chronic hepatitis B virus infection (CHB); iv)filed for regulatory clearance to begin a Phase 1/2a study of ARO-C3 and subsequently dosed the first subjects in AROC3-1001, a Phase 1/2 clinical study of ARO-C3, the Company’s investigational RNA interference (RNAi) therapeutic designed to reduce production of complement component 3 (C3) as a potential therapy for various complement mediated diseases; v)presented additional interim clinical data from AROHSD1001, AROAAT2002, and AROAPOC31001; vi)completed the purchase of 13 acres of land in the Verona Technology Park in Verona, Wisconsin and held a groundbreaking ceremony on the site. The site is being developed into an approximately 160,000 square foot drug manufacturing facility and an approximately 140,000 square foot laboratory and office facility which will support the Company's process development and analytical activities. The Company also announced that it received awards for up to $16 million in tax increment financing from the city of Verona, and up to $2.5 million in refundable Wisconsin state income tax credits from the Wisconsin Economic Development Corporation (WEDC) as incentives to invest in the local community and create new jobs. Additionally, The Company entered into a lease agreement for a new 144,000 square foot laboratory and office facility in San Diego, California to support discovery activities; vii)completed enrollment in Phase 2b ARCHES-2 study of investigational ARO-ANG3 for patients with mixed dyslipidemia; viii)filed for regulatory clearance to initiate Phase 1/2a study of ARO-RAGE for treatment of Asthma; ix)filed for regulatory clearance to initiate Phase 1/2a study of ARO-MUC5AC for treatment of muco-obstructive lung disease; x)initiated and dosed the first patients in the Phase 2 GATEWAY clinical study of investigational ARO-ANG3 for the treatment of patients with homozygous familial hypercholersterolemia; xi)entered into definitive agreements to form a joint venture, Visirna Therapeutics, Inc. (“Visirna”) with Vivo Capital (“Vivo”) through which the Company and Vivo intend to expand the reach of innovative medicines in Greater China; xii)hosted a pulmonary research & development (R&D) Day to discuss the Company’s emerging pipeline of pulmonary targeted RNA interference (RNAi) therapeutic candidates that leverage its proprietary Targeted RNAi Molecule (TRIMTM) platform, including an announcement of its previously undisclosed candidate designed to reduce expression of matrix metalloproteinase 7 (MMP7) as a potential treatment for idiopathic pulmonary fibrosis (IPF); and xiii)in conjunction with Takeda, announced results from a Phase 2 clinical study (AROAAT-2002) of investigational fazirsiran (TAK-999/ARO-AAT) for the treatment of liver disease associated with alpha-1 antitrypsin deficiency (AATD), and was recently published in the New England Journal of Medicine (NEJM) and presented in an oral presentation at The International Liver Congress™ 2022 - The Annual Meeting of the European Association for the Study of the Liver (EASL). The Company is actively monitoring the ongoing COVID-19 pandemic. The financial results for the three and nine months ended June 30, 2022 were not significantly impacted by COVID-19. Operationally, the Company has experienced delays in its earlier stage programs due to a shortage in non-human primates, which are critical to the Company’s preclinical programs. Additionally, the Company has experienced delays in enrollment in its clinical trials. The Company’s operations at its research and development facilities in Madison, Wisconsin and San Diego, California, and its corporate headquarters in Pasadena, California have continued with limited impact, other than for enhanced safety measures and intermittent lab supply shortages. However, the Company cannot predict the impact the progression of COVID-19 will have on future financial and operational results due to a variety of factors, including the ability of the Company’s clinical sites to continue to enroll subjects, the ability of the Company’s suppliers to continue to operate, the continued good health and safety of the Company’s employees and the length and severity of the COVID-19 pandemic. Liquidity The Consolidated Financial Statements have been prepared in conformity with the accounting principles generally accepted in the United States of America (“GAAP”), which contemplate the continuation of the Company as a going concern. Historically, the Company’s primary sources of financing have been through the sale of its securities and revenue from its licensing and collaboration agreements. Research and development activities have required significant capital investment since the Company’s inception and are expected to continue to require significant cash expenditure in the future, particularly as the Company’s pipeline of drug candidates and its headcount have both expanded significantly. Additionally, significant capital investment will be required as the Company’s pipeline matures into later stage clinical trials, as well as with the Company’s plans to increase its internal manufacturing capabilities, and expand its footprint in Verona, Wisconsin and San Diego, California. At June 30, 2022, the Company had $139.4 million in cash and cash equivalents (including $7.4 million in restricted cash), $277.1 million in short-term investments, $0 in marketable securities and $165.9 million in long-term investments to fund operations. $60 million of our cash balance resulted from the formation of our joint venture, Viserna. During the nine months ended June 30, 2022, the Company’s cash and investments balance decreased by $31.0 million, which was primarily due to cash being used to fund the Company’s operations, partially offset by the $120.0 million upfront payment received from GSK, and $60 million cash infusion to Viserna. In total, the Company remains eligible for $4.9 billion in developmental, regulatory and sales milestones and various royalties on net sales from its licensing and collaboration agreements. The revenue recognition for these collaboration agreements is discussed further in Note 2 below. Summary of Significant Accounting Policies There have been no changes to the significant accounting policies disclosed in the Company’s most recent Annual Report on Form 10-K. Recent Accounting Pronouncements There have been no recent accounting pronouncements that have significantly impacted this Quarterly Report on Form 10-Q, beyond those disclosed in the Company’s most recent Annual Report on Form 10-K. Basis of Presentation The accompanying unaudited consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“US GAAP”) for interim financial information. Accordingly, they do not include all of the information and notes required by US GAAP for complete financial statements. In our opinion, the unaudited consolidated financial statements have been prepared on the same basis as audited consolidated financial statements and include all adjustments, consisting of only normal recurring adjustments, necessary for the fair presentation of our financial position, results of operations, comprehensive income and cash flows. The interim results are not necessarily indicative of the results of operations to be expected for the year ending September 30, 2022 or any other period. The accompanying unaudited consolidated financial statements include the accounts of our wholly owned subsidiaries, as well as the accounts of Visirna, a variable interest entity for which we are the primary beneficiary. All intercompany balances and transactions have been eliminated in consolidation. For consolidated entities where we own or are exposed to less than 100% of the economics, we record net income (loss) attributable to noncontrolling interest in our unaudited consolidated statements of income equal to the percentage of the economic or ownership interest retained in such entities by the respective noncontrolling parties. The accompanying unaudited consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended September 30, 2021, filed with the SEC.

Collaboration and License Agreements	9 Months Ended
Collaboration and License Agreements	Jun. 30, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Collaboration and License Agreements	COLLABORATION AND LICENSE AGREEMENTS Amgen Inc. On September 28, 2016, the Company entered into two collaboration and license agreements and a common stock purchase agreement with Amgen. Under the Second Collaboration and License Agreement (the “Olpasiran Agreement”), Amgen has received a worldwide, exclusive license to Arrowhead’s novel RNAi Olpasiran (previously referred to as AMG 890 or ARO-LPA) program. These RNAi molecules are designed to reduce elevated lipoprotein(a), which is a genetically validated, independent risk factor for atherosclerotic cardiovascular disease. Under the prior collaboration and license agreement (the “First Collaboration and License Agreement” or the “ARO-AMG1 Agreement”), Amgen received an option to a worldwide, exclusive license for ARO-AMG1, an RNAi therapy for an undisclosed genetically validated cardiovascular target. Under both agreements, Amgen is wholly responsible for clinical development and commercialization. Under the terms of the agreements taken together, the Company has received $35.0 million in upfront payments, $21.5 million in the form of an equity investment by Amgen in the Company’s Common Stock, and $30.0 million in milestone payments, and may receive up to an additional $400.0 million in remaining development, regulatory and sales milestone payments. The Company is further eligible to receive up to low double-digit royalties for sales of products under the Olpasiran Agreement. In July 2019, Amgen informed the Company that it would not be exercising its option for an exclusive license for ARO-AMG1, and as such, there will be no further milestone or royalty payments under the ARO-AMG1 Agreement. The Company has evaluated these agreements in accordance with FASB Topics 808 – Collaboration Arrangements and 606 - Revenue for Contracts from Customers. The Company has substantially completed its performance obligations under the Olpasiran Agreement and the ARO-AMG1 Agreement. Future milestones and royalties achieved will be recognized in their entirety when earned. In July 2020, Amgen initiated a Phase 2 clinical study of Olpasiran, which resulted in a $20.0 million milestone payment to the Company. During the three and nine months ended June 30, 2022 and 2021, the Company recognized $0 and $0 of revenue associated with its agreement with Amgen, respectively. As of June 30, 2022, there were $0 in contract assets recorded as accounts receivable and $0 contract liabilities recorded as current deferred revenue on the Company’s Consolidated Balance Sheets. Janssen Pharmaceuticals, Inc. On October 3, 2018, the Company entered into a License Agreement (the “Janssen License Agreement”) and a Research Collaboration and Option Agreement (the “Janssen Collaboration Agreement”) with Janssen, part of the Janssen Pharmaceutical Companies of Johnson & Johnson. The Company also entered into a stock purchase agreement with JJDC (“JJDC Stock Purchase Agreement”). Under the Janssen License Agreement, Janssen has received a worldwide, exclusive license to the Company’s JNJ-3989 (ARO-HBV) program, the Company’s third-generation subcutaneously administered RNAi therapeutic candidate being developed as a potential therapy for patients with chronic hepatitis B virus infection. Beyond the Company’s Phase 1/2 study of JNJ-3989 (ARO-HBV), which the Company was responsible for completing, Janssen is wholly responsible for clinical development and commercialization of JNJ-3989. Under the Janssen Collaboration Agreement, Janssen was able to select three new targets against which Arrowhead would develop clinical candidates. These candidates were subject to certain restrictions and do not include candidates that already were in the Company’s pipeline. The Company was obligated to perform discovery, optimization and preclinical research and development, entirely funded by Janssen, which on its own or in combination with Janssen development work, would have been sufficient to allow the filing of a U.S. Investigational New Drug Application or equivalent, at which time Janssen would have the option to take an exclusive license. If the option was exercised, Janssen would have been wholly responsible for clinical development and commercialization of each optioned candidate. Under the terms of the agreements taken together, the Company has received $175.0 million as an upfront payment, $75.0 million in the form of an equity investment by JJDC in Arrowhead Common Stock under the JJDC Stock Purchase Agreement, and milestone and option payments totaling $73.0 million, and the Company may receive up to $1.6 billion in development and sales milestones payments for the Janssen License Agreement, and up to $0.6 billion in development and sales milestone payments for the remaining target covered under the Janssen Collaboration Agreement. The Company is further eligible to receive tiered royalties on product sales up to mid-teens under the Janssen License Agreement and up to low teens under the Janssen Collaboration Agreement. During the three months ended June 30, 2022, Janssen’s option period expired unexercised for two of the three candidates (ARO-JNJ2 and ARO-JNJ3) under the Janssen Collaboration Agreement. The Company has evaluated these agreements in accordance with FASB Topics 808 – Collaboration Arrangements and 606 - Revenue for Contracts from Customers. At the inception of these agreements, the Company identified one distinct performance obligation. Regarding the Janssen License Agreement, the Company determined that the key deliverables included the license and certain R&D services including the Company’s responsibility to complete the Phase 1/2 study of JNJ-3989 (ARO-HBV) and the Company’s responsibility to ensure certain manufacturing of JNJ-3989 (ARO-HBV) drug product is completed and delivered to Janssen (the “Janssen R&D Services”). Due to the specialized and unique nature of these Janssen R&D Services and their direct relationship with the license, the Company determined that these deliverables represent one distinct bundle and, thus, one performance obligation. The Company also determined that Janssen’s option to require the Company to develop up to three new targets is not a material right and, thus, not a performance obligation at the onset of the agreement. The consideration for this option is accounted for separately. The Company determined the transaction price totaled approximately $252.7 million, which includes the upfront payment, the premium paid by JJDC for its equity investment in the Company, two $25.0 million milestone payments related to JNJ-3989 (ARO-HBV), and estimated payments for reimbursable Janssen R&D Services to be performed. The Company has allocated the total $252.7 million initial transaction price to its one distinct performance obligation for the JNJ-3989 (ARO-HBV) license and the associated Janssen R&D Services. The Company has recognized this transaction price in its entirety as of September 30, 2021, as its performance obligations were substantially completed. Future milestones and royalties achieved will be recognized in their entirety when earned. During the three months ended June 30, 2022 and 2021, the Company recognized approximately $0 and $0 of revenue associated with this performance obligation, respectively. During the nine months ended June 30, 2022 and 2021, the Company recognized approximately $0 and $20.2 million of revenue associated with this performance obligation, respectively. As of June 30, 2022, there were $0 in contract assets recorded as accounts receivable, and $0 of contract liabilities recorded as current deferred revenue on the Company’s Consolidated Balance Sheets. The Company has conducted its discovery, optimization and preclinical research and development of JNJ-75220795 (ARO-JNJ1), ARO-JNJ2, and ARO-JNJ3 under the Janssen Collaboration Agreement. All costs and labor hours spent by the Company have been entirely funded by Janssen. During the three months ended June 30, 2022, Janssen’s option period expired unexercised for two of the three candidates (ARO-JNJ2 and ARO-JNJ3) under the Janssen Collaboration Agreement as reported in the second quarter of 2022. During the three months ended June 30, 2022 and 2021, the Company recognized $0.0 million and $0.2 million of revenue associated with these efforts, respectively. During the nine months ended June 30, 2022 and 2021, the Company recognized $0.1 million and $0.5 million of revenue associated with these efforts, respectively. In May 2021, Janssen exercised its option right for ARO-JNJ1, which resulted in a $10.0 million milestone payment to the Company. This $10 million milestone payment was recognized entirely during the three months ended June 30, 2021. As of June 30, 2022, there were $0 of contract assets recorded as accounts receivable and $0 of contract liabilities recorded as current deferred revenue on the Company’s Consolidated Balance Sheets. Takeda Pharmaceuticals U.S.A., Inc. On October 7, 2020, the Company entered into an Exclusive License and Co-funding agreement (the “Takeda License Agreement”) with Takeda. Under the Takeda License Agreement, Takeda and the Company will co-develop the Company’s ARO-AAT program, the Company’s second-generation subcutaneously administered RNAi therapeutic candidate being developed as a treatment for liver disease associated with alpha-1 antitrypsin deficiency. Within the United States, ARO-AAT, if approved, will be co-commercialized under a 50/50 profit sharing structure. Outside the United States, Takeda will lead the global commercialization strategy and will receive an exclusive license to commercialize ARO-AAT, while the Company will be eligible to receive tiered royalties of 20% to 25% on net sales. In January 2021, the Company received $300.0 million as an upfront payment and is eligible to receive potential development, regulatory and commercial milestones of up to $740.0 million. The Company has evaluated the Takeda License Agreement in accordance with FASB Topics 808 – Collaborative Arrangements and 606 - Revenue for Contracts from Customers. At the inception of the Takeda License Agreement, the Company identified one distinct performance obligation. The Company determined that the key deliverables included the license and certain R&D services including the Company’s responsibilities to complete the initial portion of the SEQUOIA study, to complete the ongoing Phase 2 AROAAT2002 study and to ensure certain manufacturing of ARO-AAT drug product is completed and delivered to Takeda (the “Takeda R&D Services”). Due to the specialized and unique nature of these Takeda R&D Services and their direct relationship with the license, the Company determined that these deliverables represent one distinct bundle and, thus, one performance obligation. Beyond the Takeda R&D Services, which are the responsibility of the Company, Takeda will be responsible for managing future clinical development and commercialization outside the United States. Within the United States, the Company will also participate in co-development and co-commercialization efforts and will co-fund these efforts with Takeda as part of the 50/50 profit sharing structure within the United States. The Company considers the collaborative activities, including the co-development and co-commercialization, to be a separate unit of account within Topic 808, and as such, these co-funding amounts will be recorded as Research and Development Expenses or General and Administrative Expenses, as appropriate. The Company determined the initial transaction price totaled $300.0 million, which includes the upfront payment. The Company has excluded any future milestones or royalties from this transaction price to date. The Company has allocated the total $300.0 million initial transaction price to its one distinct performance obligation for the ARO-AAT license and the associated Takeda R&D Services. Revenue will be recognized using a proportional performance method (based on actual patient visits completed versus total estimated visits completed for the ongoing SEQUOIA and AROAAT2002 clinical studies). Revenue for the three months ended June 30, 2022 and 2021 was $25.5 million and $35.7 million, respectively. Revenue for the nine months ended June 30, 2022 and 2021 was $67.1 million and $69.3 million, respectively. As of June 30, 2022, there were $0 in contract assets recorded as accounts receivable, $71.0 million in contract liabilities recorded as deferred revenue and $71.2 million in contract liabilities recorded as deferred revenue, net of the current portion, and $7.8 million in contract liabilities recorded as accrued expenses. The $7.8 million in accrued expenses was primarily driven by co-development and co-commercialization activities. Horizon Therapeutics Ireland DAC On June 18, 2021, the Company entered into the Horizon License Agreement with Horizon. Under the Horizon License Agreement, Horizon received a worldwide exclusive license for ARO-XDH, a previously undisclosed discovery-stage investigational RNAi therapeutic being developed by the Company as a potential treatment for people with uncontrolled gout. The Company will conduct all activities through the preclinical stages of development of ARO-XDH, and Horizon will be wholly responsible for clinical development and commercialization of ARO-XDH. In July 2021, the Company received $40 million as an upfront payment and is eligible to receive up to $660 million in potential development, regulatory and sales milestones. The Company is also eligible to receive royalties in the low- to mid-teens range on net product sales. The Company has evaluated the Horizon License Agreement in accordance with FASB Topics 808 – Collaborative Arrangements and 606 - Revenue for Contracts from Customers. At the inception of the Horizon License Agreement, the Company identified one distinct performance obligation. The Company determined that the key deliverables included the license and certain R&D services, including the Company’s responsibilities to conduct all activities through the preclinical stages of development of ARO-XDH (the “Horizon R&D Services”). Due to the specialized and unique nature of these Horizon R&D Services and their direct relationship with the license, the Company determined that these deliverables represented one distinct bundle and, thus, one performance obligation. Beyond the Horizon R&D Services, which are the responsibility of the Company, Horizon will be responsible for managing future clinical development and commercialization of ARO-XDH. The Company determined the initial transaction price totaled $40.0 million, including the upfront payment. The Company has excluded any future estimated milestones or royalties, from this transaction price to date. The Company will allocate the total $40.0 million initial transaction price to its one distinct performance obligation for the ARO-XDH license and the associated Horizon R&D Services. Revenue will be recognized on a straight-line basis over the estimated timeframe for completing the Horizon R&D Services. The Company determined that the straight-line basis was appropriate as its efforts will be expended evenly over the course of completing its performance obligation. Revenue for the three months ended June 30, 2022 and 2021 was $6.7 million and $0, respectively. Revenue for the nine months ended June 30, 2022 and 2021 was $20.0 million and $0, respectively. As of June 30, 2022, there were $0 million in contract assets recorded as accounts receivable, $13.3 million in contract liabilities recorded as deferred revenue. The Company has manufactured ARO-XDH material for Horizon in furtherance of the research plan entered into pursuant to the Horizon License Agreement, for which the Company has been reimbursed for its costs. During the nine months ended June 30, 2022 and 2021, the Company recognized $1.3 million and $0 with these efforts, respectively. As of June 30, 2022, there were $0.0 million of contract assets recorded as accounts receivable and $0 of contract liabilities recorded as current deferred revenue on the Company’s Consolidated Balance Sheets. Glaxosmithkline Intellectual Property (No. 3) Limited On November 22, 2021, the Company entered into an Exclusive License Agreement (the “GSK License Agreement”) with GSK. Under the GSK License Agreement, GSK has received an exclusive license for ARO-HSD, the Company’s investigational RNAi therapeutic being developed as a treatment for patients with alcohol-related and nonalcohol related liver diseases, such as nonalcoholic steatohepatitis (NASH). The exclusive license is worldwide with the exception of greater China, for which the Company retained rights to develop and commercialize. Beyond the Company’s Phase 1/2 study of (ARO-HSD), which the Company is responsible for completing, GSK is wholly responsible for clinical development and commercialization of ARO-HSD in its territory. Under the terms of the agreement, the Company has received an upfront payment of $120 million and is eligible for additional payments of $30 million at the start of Phase 2 and $100 million upon achieving a successful Phase 2 trial readout and the first patient dosed in a Phase 3 trial. Furthermore, should the Phase 3 trial read out positively, and the potential new medicine receives regulatory approval in major markets, the deal provides for commercial milestone payments to the Company of up to $190 million at first commercial sale, and up to $590 million in sales-related milestone payments. The Company is further eligible to receive tiered royalties on net product sales in a range of mid-teens to twenty percent. The Company has evaluated the GSK License Agreement in accordance with FASB Topics 808 – Collaborative Arrangements and 606 - Revenue for Contracts from Customers. At the inception of the GSK License Agreement, the Company identified one distinct performance obligation. The Company determined that the key deliverables included the license and certain R&D services, including the Company’s responsibility to complete the Phase 1/2 study, (the “GSK R&D Services”). Due to the specialized and unique nature of these GSK R&D Services and their direct relationship with the license, the Company determined that these deliverables represented one distinct bundle and, thus, one performance obligation. Beyond the GSK R&D Services, which are the responsibility of the Company, GSK will be responsible for managing future clinical development and commercialization in its territory. The Company determined the initial transaction price totaled $120.0 million, including the upfront payment. The $120.0 million upfront payment was collected in January 2022. The Company has excluded any future estimated milestones or royalties from this transaction price to date. The Company has allocated the total $120.0 million initial transaction price to its one distinct performance obligation for the ARO-HSD license and the associated GSK R&D Services. As the Company has completed its performance obligation related to this agreement, the upfront payment of $120.0 million will be fully recognized as of the three and nine months ended June 30, 2022. Revenue for the nine months ended June 30, 2022 and 2021 was $120.0 million and $0, respectively. As of June 30, 2022, there were $0 in contract assets recorded as accounts receivable, $0 in contract liabilities recorded as deferred revenue. Joint Venture and License Agreement with Visirna Therapeutics, Inc. On April 25, 2022, the Company entered into a License Agreement (the “Visirna License Agreement”) with Visirna Therapeutics, Inc. (“Visirna”), pursuant to which Visirna received an exclusive license to develop, manufacture and commercialize four of Arrowhead’s RNAi-based investigational cardiobolic medicines in Greater China (including the People’s Republic of China, Hong Kong, Macau and Taiwan). Pursuant to a Share Purchase Agreement entered into simultaneously with the Visirna License Agreement (the “Visirna SPA”), the Company acquired a majority stake in Visirna (after accounting for shares reserved for Visirna’s employee stock ownership plan) as partial consideration for the Visirna License Agreement. Under the Visirna SPA, entities affiliated with Vivo Capital (“Vivo”) also acquired a minority stake in Visirna in exchange for $60 million in upfront capital to support the operations of Visirna. As further consideration under the Visirna License Agreement, the Company is also eligible to receive potential royalties on commercial sales. The Company has determined that Visirna is a variable interest entity upon its formation and as of June 30, 2022, and it has been determined that Arrowhead is the primary beneficiary; accordingly, Arrowhead consolidates the financial statements of Visirna.

Property and Equipment

9 Months Ended

Jun. 30, 2022

Property, Plant and Equipment [Abstract]

Property and Equipment

PROPERTY AND EQUIPMENT

The following table summarizes the Company’s major classes of property and equipment:


	June 30, 2022		September 30, 2021
	(In thousands)
Computers, software, office equipment and furniture	$	2,210	$	2,170
Research equipment	31,678		27,500
Leasehold improvements	42,017		41,524
Construction in Progress	22,338		345
Land	2,996		—
Total gross fixed assets	101,239		71,539
Less: Accumulated depreciation and amortization	(29,335)		(22,864)
Property and equipment, net	$	71,904	$	48,675

Depreciation and amortization expense for property and equipment for the three months ended June 30, 2022 and 2021 was $2.2 million and $1.6 million, respectively. Depreciation and amortization expense for property and equipment for the nine months ended June 30, 2022 and 2021 was $6.5 million and $4.5 million, respectively. Construction in Progress relates to the Company’s Verona and San Diego research facilities. Land relates to the Company’s Verona, Wisconsin research facility.

Investments

9 Months Ended

Jun. 30, 2022

Investments, Debt and Equity Securities [Abstract]

Investments

INVESTMENTS

Investments at June 30, 2022 primarily consisted of commercial paper and corporate bonds that have maturities of less than 36 months and a certificate of deposit. Cash and cash equivalents consist of cash on hand and commercial paper purchased with 90-days or less remaining to maturity. The Company’s corporate bonds consist of both short-term and long-term bonds and are classified as “held-to-maturity” on the Company’s Consolidated Balance Sheets. The Company’s certificate of deposit matures in less than 12 months and is classified as “held-to-maturity” on the Company’s Consolidated Balance Sheet,’. The Company’s marketable equity securities consisted of mutual funds that primarily invest in U.S. government bonds, U.S. government agency bonds, corporate bonds and other asset-backed debt securities. Dividends from these funds were automatically re-invested. In April 2022, all marketable securities were sold for $122.3 million. The Company may also invest excess cash balances in money market accounts, and these securities would be classified as cash and cash equivalents on the Company’s Consolidated Balance Sheet. The Company accounts for its “held-to-maturity” investments in accordance with FASB ASC 320, Investments – Debt and Equity Securities and its marketable equity securities in accordance with ASC 321, Investments – Equity Securities. We did not record any impairment charges related to our marketable debt securities during the three and nine months ended June 30, 2022.

The following tables summarize the Company’s short-term and long-term investments and marketable securities as of June 30, 2022 and September 30, 2021 by measurement category:


	As of June 30, 2022
	(In thousands)
	Cost Basis		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value
Classified as Cash Equivalents
Commercial notes (due within ninety days)	$	25,325	$	11	$	—	$	25,336
Classified as Held to Maturity
Commercial notes (due within one year)	$	227,057	$	21	$	(1,588)	$	225,490
Commercial notes (due within one through three years)	$	165,920	$	—	$	(6,380)	$	159,540
Certificate of deposit (due within one year)	$	50,000	$	—	$	—	$	50,000
Classified as Marketable Securities
Marketable securities	$	—	$	—	$	—	$	—
Total	$	468,302	$	32	$	(7,968)	$	460,366

	As of September 30, 2021
	(In thousands)
	Cost Basis		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value
Classified as Held to Maturity
Commercial notes (due within one year)	$	56,627	$	803	$	—	$	57,430
Commercial notes (due within one through three years)	$	195,595	$	1,151	$	(103)	$	196,643
Certificate of deposit (due within one through two years)	$	50,000	$	—	$	—	$	50,000
Classified as Marketable Securities
Marketable securities	$	127,481	$	—	$	(753)	$	126,728
Total	$	429,703	$	1,954	$	(856)	$	430,801

Intangible Assets

9 Months Ended

Jun. 30, 2022

Goodwill and Intangible Assets Disclosure [Abstract]

Intangible Assets

INTANGIBLE ASSETSIntangible assets subject to amortization include patents and a license agreement capitalized as part of the Novartis RNAi asset acquisition in March 2015. The license agreement associated with the Novartis RNAi asset acquisition is being amortized over the estimated life remaining at the time of acquisition, which was 21 years, and the accumulated amortization of the asset is $1.1 million. The patents associated with the Novartis RNAi asset acquisition are being amortized over the estimated life remaining at the time of acquisition, which was 14 years, and the accumulated

amortization of the assets is $11.4 million. Amortization expense for the three months ended June 30, 2022 and 2021 was $0.4 million and $0.4 million, respectively. Amortization expense for the nine months ended June 30, 2022 and 2021 was $1.3 million and $1.3 million, respectively. Amortization expense is expected to be $0.4 million for the remainder of fiscal 2022, $1.7 million in 2023, $1.7 million in 2024, $1.7 million in 2025, $1.7 million in 2026 and $5.2 million thereafter.

The following table provides details on the Company’s intangible asset balances:


	Intangible Assets Subject to Amortization
	(in thousands)
Balance at September 30, 2021	$	13,663
Impairment	—
Amortization	(1,276)
Balance at June 30, 2022	$	12,387

Stockholders' Equity	9 Months Ended
Stockholders' Equity	Jun. 30, 2022
Equity [Abstract]
Stockholders' Equity	STOCKHOLDERS’ EQUITY At June 30, 2022, the Company had a total of 150,000,000 shares of capital stock authorized for issuance, consisting of 145,000,000 shares of Common Stock, par value $0.001 per share, and 5,000,000 shares of Preferred Stock, par value $0.001 per share. At June 30, 2022, 105,795,456 shares of Common Stock were outstanding. At June 30, 2022, 13,942,716 shares of Common Stock were reserved for issuance upon exercise of options and vesting of restricted stock units granted or available for grant under Arrowhead’s 2004 Equity Incentive Plan, 2013 Incentive Plan, and 2021 Incentive Plan, as well as for inducement grants made to new employees under Rule 5635(c)(4) of the Nasdaq Listing Rules. In August 2020, the Company entered into an Open Market Sale Agreement (the “ATM Agreement”), pursuant to which the Company may, from time to time, sell up to $250,000,000 in shares of the Company’s Common Stock through Jefferies LLC, acting as the sales agent and/or principal, in an at-the-market offering. The Company is not required to sell shares under the ATM Agreement. The Company will pay Jefferies LLC a commission of up to 3.0% of the aggregate gross proceeds received from all sales of the common stock under the ATM Agreement. Unless otherwise terminated, the ATM Agreement continues until the earlier of selling all shares available under the ATM Agreement or December 2, 2022. At June 30, 2022, no shares have been sold under the ATM Agreement.

- Definition

The entire disclosure for shareholders' equity comprised of portions attributable to the parent entity and noncontrolling interest, including other comprehensive income. Includes, but is not limited to, balances of common stock, preferred stock, additional paid-in capital, other capital and retained earnings, accumulated balance for each classification of other comprehensive income and amount of comprehensive income.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
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Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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-Paragraph 13
-Subparagraph (b)
-URI https://asc.fasb.org/extlink&oid=126973232&loc=SL123496158-112644

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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-Subparagraph (c)
-URI https://asc.fasb.org/extlink&oid=126973232&loc=SL123496171-112644

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
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-Paragraph 14
-Subparagraph (b)
-URI https://asc.fasb.org/extlink&oid=126973232&loc=SL123496171-112644

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
-Section S99
-Paragraph 1
-Subparagraph (SX 210.3-04)
-URI https://asc.fasb.org/extlink&oid=120397183&loc=d3e187085-122770

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
-SubTopic 10
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-Paragraph 18
-Subparagraph (d)
-URI https://asc.fasb.org/extlink&oid=126973232&loc=SL123496189-112644

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
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-Paragraph 18
-Subparagraph (a)
-URI https://asc.fasb.org/extlink&oid=126973232&loc=SL123496189-112644

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 505
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-URI https://asc.fasb.org/extlink&oid=126973232&loc=SL123496158-112644

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
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Reference 12: http://www.xbrl.org/2003/role/disclosureRef
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
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Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
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-Topic 505
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Reference 15: http://www.xbrl.org/2003/role/disclosureRef
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Reference 16: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

Commitments and Contingencies	9 Months Ended
Commitments and Contingencies	Jun. 30, 2022
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	COMMITMENTS AND CONTINGENCIES Litigation From time to time, the Company may be subject to various claims and legal proceedings in the ordinary course of business. If the potential loss from any claim, asserted or unasserted, or legal proceeding is considered probable and the amount is reasonably estimable, the Company will accrue a liability for the estimated loss. There were no contingent liabilities recorded as of June 30, 2022. Commitments On December 20, 2021, the Company completed a purchase of 13 acres of land in the Verona Technology Park in Verona, Wisconsin, which is planned to be the site of an approximately 160,000 square foot drug manufacturing facility and an approximately 140,000 square foot laboratory and office facility to support process development and analytical activities. Arrowhead intends to invest between $200 million and $250 million into the buildout of the facilities. As part of this acquisition, the Company also entered into a development agreement with the City of Verona to construct certain infrastructure improvements within the TIF district, and will be reimbursed by the City of Verona by future tax increment revenue generated from the developed property. The total amount of funding that City of Verona will pay as reimbursements under the TIF program for these improvements is not guaranteed and will depend on future tax revenues generated from the developed property. Technology License CommitmentsThe Company has licensed from third parties the rights to use certain technologies for its research and development activities, as well as in any products the Company may develop using these licensed technologies. These agreements and other similar agreements often require milestone and royalty payments. Milestone payments, for example, may be required as the research and development process progresses through various stages of development, such as when clinical candidates enter or progress through clinical trials, upon a new drug application and upon certain sales level milestones. These milestone payments could amount to the mid to upper double-digit millions of dollars. During the three and nine months ended June 30, 2022 and 2021, the Company did not reach any milestones. Under certain agreements, the Company may be required to make mid to high single-digit percentage royalty payments based on a percentage of sales of the relevant products.

Leases

9 Months Ended

Jun. 30, 2022

Leases [Abstract]

Leases

LEASES

Leases

In April 2019, the Company entered into a lease for its corporate headquarters in Pasadena, California. The 91 month office building lease between the Company and 177 Colorado Owner, LLC is for approximately 24,000 square feet of office space located at 177 E. Colorado Blvd, Pasadena, California. The increased capacity of this new office space compared to the Company’s prior corporate headquarters will accommodate increased personnel as the Company’s pipeline of drug candidates expands and moves closer to market. Lease payments began on September 30, 2019 and are estimated to total approximately $8.7 million over the term. The lease expires on April 30, 2027. The Company has paid approximately $3.5 million for leasehold improvements, net of tenant improvement allowances. The lease contains an option to renew for one term of five years. The exercise of this option was not determined to be reasonably certain and thus was not included in lease liabilities on the Company’s Consolidated Balance Sheet at June 30, 2022. On October 23, 2020, the Company entered into a lease expansion to add an additional approximately 24,000 square feet of office space at the same location for its corporate headquarters. Lease payments for the expansion began in July 2021 and the lease for the expansion expires in April 2027. The lease payments for the expansion are expected to total $6.9 million. The Company has paid approximately $4.0 million of leasehold improvements, net of tenant improvement allowances, for the lease expansion.

In January 2016, the Company entered into a lease for its research facility in Madison, Wisconsin. The lease was for approximately 60,000 square feet of office and laboratory space and had an expiration date of September 30, 2026. The lease was amended in January 2019 and May 2020 to expand the rentable square feet by an additional 40,000 square feet and to extend the lease expiration date to September 30, 2031. Lease payments are estimated to total approximately $26.2 million for the term. The Company incurred approximately $11.0 million of leasehold improvements for the additional 40,000 square feet, net of tenant improvement allowances. The lease contains two options to renew for two terms of five years. The exercise of these options were not determined to be reasonably certain and thus was not included in lease liabilities on the Company’s Consolidated Balance Sheet at June 30, 2022. In November 2020 and December 2020, the Company entered into amendments to expand the rentable square space by an additional 10,743 square feet and these amendments added a total of approximately $1.2 million of lease payments for the remainder of the term.

In March 2020, the Company entered into a sublease agreement for additional research and development facility space in San Diego, California. The Sublease provides additional space needed to accommodate the recent growth of the Company’s personnel and discovery efforts. The Sublease is for approximately 21,000 rentable square feet. The term of the Sublease commenced on April 1, 2020 and will end on January 14, 2023. Sublease payments are estimated to total approximately $2.0 million over the term.

On November 19, 2021, the Company entered into a new lease for a San Diego, California research facility. The 15-year lease is for approximately 144,000 square feet of office and research and development laboratory space to be constructed in San Diego, California. This lease will replace the Company’s current research facility sublease for property located in San Diego, California. The increased capacity of this new facility compared to the Company’s current research facility in San Diego will accommodate increased personnel for the Company’s expanding pipeline of current and future drug candidates. The estimated rent commencement date for the lease is in March 2023, after construction and leasehold improvements have been completed. The lease payments, which begin on the rent commencement date, will be approximately $119.0 million over the initial 15-year term. The Company also estimates payments for operating expenses to be approximately $3.0 million for the first year of the lease, and these payments will continue throughout the initial 15-year term. The Company expects to pay approximately $31.0 million for leasehold improvements, net of tenant improvement allowances. Pursuant to the lease, within twelve months of the expiration of the initial 15-year term, the

Company has the option to extend the lease for up to one additional ten-year term, with certain annual increases in base rent. .

Operating lease cost during the three months ended June 30, 2022 and 2021 was $3.4 million and $1.6 million, respectively. Operating lease cost during the nine months ended June 30, 2022 and 2021 was $6.0 million and $3.6 million, respectively. Variable lease costs for the three months ended June 30, 2022 and 2021 was $0.2 million and $0.1 million, respectively. Variable lease costs for the nine months ended June 30, 2022 and 2021 was $0.5 million and $0.6 million, respectively. There was no short-term lease cost during the three and nine months ended June 30, 2022 and 2021.

The following table presents payments of operating lease liabilities on an undiscounted basis as of June 30, 2022:


	(in thousands)
2022 (remainder of fiscal year)	$	1,309
2023	5,802
2024	8,094
2025	11,800
2026	12,313
2027 and thereafter	114,109
Total	$	153,427
Less imputed interest	$	(72,313)
Total operating lease liabilities (includes current portion)	$	81,114

Cash paid for the amounts included in the measurement of the operating lease liabilities on the Company’s Consolidated Balance Sheet and included in Other changes in operating assets and liabilities within cash flows from operating activities on the Company’s Consolidated Statements of Cash Flows for the nine months ended June 30, 2022 and 2021 was $3.4 million and $2.2 million, respectively. The weighted-average remaining lease term and weighted-average discount rate for all leases as of June 30, 2022 was 7.3 years and 8.5%, respectively.

Stock-Based Compensation

9 Months Ended

Jun. 30, 2022

Share-Based Payment Arrangement [Abstract]

Stock-Based Compensation

STOCK-BASED COMPENSATIONArrowhead has three plans that provide for equity-based compensation. Under the 2004 Equity Incentive Plan and the 2013 Incentive Plan, as of June 30, 2022, 216,607 and 4,114,999 shares, respectively, of Arrowhead’s Common Stock are reserved for the grant of stock options, stock appreciation rights, and restricted stock unit awards to employees, consultants and others. No further grants may be made under the 2004 Equity Incentive Plan. As of June 30, 2022, there were options granted and outstanding to purchase 216,607 and 1,806,987 shares of Common Stock under the 2004 Equity Incentive Plan and the 2013 Incentive Plan, respectively, and there were 2,308,012 restricted stock units granted and outstanding under the 2013 Incentive Plan. As of June 30, 2022, there were 816,248 shares reserved for options and 682,500 shares reserved for restricted stock units issued as inducement grants to new employees outside of equity compensation plans. As of June 30, 2022, there were 3,000 shares of Common Stock reserved for options and 1,507,267 shares of Common Stock reserved for restricted stock units granted and outstanding under the 2021 Incentive Plan. As of June 30, 2022, the total number of shares available under the 2021 Incentive Plan was 6,627,845 shares, which includes 119,612 shares that were forfeited under the 2013 Incentive Plan.

Stock Options

The following table summarizes information about stock options:


	Number of Options Outstanding	Weighted- Average Exercise Price Per Share		Weighted- Average Remaining Contractual Term	Aggregate Intrinsic Value
Balance at September 30, 2021	3,456,239	$	19.60
Granted	—	—
Cancelled	(106,801)	43.68
Exercised	(506,596)	8.45
Balance at June 30, 2022	2,842,842	$	20.60	5.1 years	$	55,434,252
Exercisable at June 30, 2022	2,370,089	$	16.14	4.6 years	$	52,941,990

Stock-based compensation expense related to stock options for the three months ended June 30, 2022 and 2021 was $2.6 million and $3.2 million, respectively. Stock-based compensation expense related to stock options for the nine months ended June 30, 2022 and 2021 was $8.3 million and $9.6 million, respectively. For non-qualified stock options, the expense creates a timing difference, resulting in a deferred tax asset, which is fully reserved by a valuation allowance.

The grant date fair value of the options granted by the Company for the three months ended June 30, 2022 and 2021 was $0 and $0.9 million, respectively. The grant date fair value of the options granted by the Company for the nine months ended June 30, 2022 and 2021 was $0 and $9.0 million, respectively.

The intrinsic value of the options exercised during the three months ended June 30, 2022 and 2021 was $1.6 million and $10.2 million, respectively. The intrinsic value of the options exercised during the nine months ended June 30, 2022 and 2021 was $24.9 million and $63.0 million, respectively.

As of June 30, 2022, the pre-tax compensation expense for all outstanding unvested stock options in the amount of $14.9 million will be recognized in the Company’s results of operations over a weighted average period of 1.7 years.

The fair value of each stock option award is estimated on the date of grant using the Black-Scholes option pricing model. The Black-Scholes option valuation model was developed for use in estimating the fair value of traded options, which do not have vesting restrictions and are fully transferable. The determination of the fair value of each stock option is affected by the Company’s stock price on the date of grant, as well as assumptions regarding a number of highly complex and subjective variables. Because the Company’s employee stock options have characteristics significantly different from those of traded options, and because changes in the subjective input assumptions can materially affect the fair value estimate, in management’s opinion, the existing models do not necessarily provide a reliable single measure of the fair value of its employee stock options.

The assumptions used to value stock options are as follows:


	Nine Months Ended June 30,
	2022	2021
Dividend yield	N/A	—
Risk-free interest rate	N/A	0.4% - 1.1%
Volatility	N/A	86% - 90.4%
Expected life (in years)	N/A	6.25
Weighted average grant date fair value per share of options granted	N/A	$	48.64

The dividend yield is zero as the Company currently does not pay a dividend.

The risk-free interest rate is based on that of the U.S. Treasury bond.

Volatility is estimated based on volatility average of the Company’s Common Stock price.

Restricted Stock Units

Restricted stock units (“RSUs”), including time-based, market condition-based, and performance condition-based awards, have been granted under the Company’s 2013 Incentive Plan, 2021 Incentive Plan, and as inducements grants granted outside of the Company’s equity-based compensation plans under Rule 5635(c)(4) of the Nasdaq Listing Rules. At vesting, each outstanding RSU will be exchanged for one share of the Company’s Common Stock. RSU awards generally vest subject to the satisfaction of service requirements or the satisfaction of both service requirements and achievement of certain performance targets.

The following table summarizes the activity of the Company’s RSUs:


	Number of RSUs	Weighted- Average Grant Date Fair Value Per Share
Unvested at September 30, 2021	3,831,850	$	61.24
Granted	1,691,367	56.73
Vested	(962,188)	49.10
Forfeited	(95,625)	69.32
Unvested at June 30, 2022	4,465,404	$	61.97

During the three months ended June 30, 2022 and 2021, the Company recorded $33.7 million and $15.4 million of expense related to RSUs, respectively. During the nine months ended June 30, 2022 and 2021, the Company recorded $83.4 million and $32.5 million of expense related to RSUs, respectively. Such expense is included in stock-based compensation expense in the Company’s Consolidated Statements of Operations and Comprehensive Income (Loss). For RSUs, the expense creates a timing difference, resulting in a deferred tax asset, which is fully reserved by a valuation allowance.

For RSUs, the grant date fair value of the award is based on the Company’s closing stock price at the grant date, with consideration given to the probability of achieving performance conditions for performance-based awards. The grant date fair value of the RSUs granted by the Company for the three months ended June 30, 2022 and 2021 was $42.5 million and $3.1 million, respectively. The grant date fair value of the RSUs granted by the Company for the nine months ended June 30, 2022 and 2021 was $95.2 million and $112.1 million, respectively.

As of June 30, 2022, the pre-tax compensation expense for all unvested RSUs in the amount of $190.3 million will be recognized in the Company’s results of operations over a weighted average period of 2.7 years.

Fair Value Measurements

9 Months Ended

Jun. 30, 2022

Fair Value Disclosures [Abstract]

Fair Value Measurements

FAIR VALUE MEASUREMENTS

The Company measures its financial assets and liabilities at fair value. Fair value is defined as the price that would be received to sell an asset or paid to transfer a liability (i.e., exit price) in an orderly transaction between market participants at the measurement date. Additionally, the Company is required to provide disclosure and categorize assets and liabilities measured at fair value into one of three different levels depending on the assumptions (i.e., inputs) used in the valuation. Level 1 provides the most reliable measure of fair value while Level 3 generally requires significant management judgment. Financial assets and liabilities are classified in their entirety based on the lowest level of input significant to the fair value measurement. The fair value hierarchy is defined as follows:

Level 1—Valuations are based on unadjusted quoted prices in active markets for identical assets or liabilities.

Level 2—Valuations are based on quoted prices for similar assets or liabilities in active markets, or quoted prices in markets that are not active for which significant inputs are observable, either directly or indirectly.

Level 3—Valuations are based on prices or valuation techniques that require inputs that are both unobservable and significant to the overall fair value measurement. Inputs reflect management’s best estimate of what market participants would use in valuing the asset or liability at the measurement date.

The following table summarizes fair value measurements at June 30, 2022 and September 30, 2021 for assets and liabilities measured at fair value on a recurring basis:

June 30, 2022:


	Level 1		Level 2		Level 3		Total
	(in thousands)
Classified as Cash and cash equivalents
Commercial Notes	$	—	$	25,336	$	—	$	25,336
Classified as Marketable Securities
Marketable securities	$	—	$	—	$	—	$	—
Classified as Held to Maturity
Short-term investments	$	—	$	225,490	$	—	$	225,490
Long-term investments	$	—	$	159,540	$	—	$	159,540
Certificate of deposits	$	50,000	$	—	$	—	$	50,000
Classified as Contingent Consideration
Contingent consideration	$	—	$	—	$	—	$	—

September 30, 2021:


	Level 1		Level 2		Level 3		Total
	(in thousands)
Classified as Marketable Securities
Marketable securities	$	126,728	$	—	$	—	$	126,728
Classified as Held to Maturity
Short-term investments	$	—	$	57,430	$	—	$	57,430
Long-term investments	$	—	$	196,643	$	—	$	196,643
Certificate of deposit	$	50,000	$	—	$	—	$	50,000
Classified as Contingent Consideration
Contingent consideration	$	—	$	—	$	—	$	—

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

Subsequent Events	9 Months Ended
Subsequent Events	Jun. 30, 2022
Subsequent Events [Abstract]
Subsequent Events	SUBSEQUENT EVENTSNone.

Organization and Significant Accounting Policies (Policies)	9 Months Ended
	Jun. 30, 2022
Accounting Policies [Abstract]
Recent Accounting Pronouncements	Recent Accounting Pronouncements There have been no recent accounting pronouncements that have significantly impacted this Quarterly Report on Form 10-Q, beyond those disclosed in the Company’s most recent Annual Report on Form 10-K.
Basis of Presentation	Basis of Presentation The accompanying unaudited consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“US GAAP”) for interim financial information. Accordingly, they do not include all of the information and notes required by US GAAP for complete financial statements. In our opinion, the unaudited consolidated financial statements have been prepared on the same basis as audited consolidated financial statements and include all adjustments, consisting of only normal recurring adjustments, necessary for the fair presentation of our financial position, results of operations, comprehensive income and cash flows. The interim results are not necessarily indicative of the results of operations to be expected for the year ending September 30, 2022 or any other period. The accompanying unaudited consolidated financial statements include the accounts of our wholly owned subsidiaries, as well as the accounts of Visirna, a variable interest entity for which we are the primary beneficiary. All intercompany balances and transactions have been eliminated in consolidation. For consolidated entities where we own or are exposed to less than 100% of the economics, we record net income (loss) attributable to noncontrolling interest in our unaudited consolidated statements of income equal to the percentage of the economic or ownership interest retained in such entities by the respective noncontrolling parties. The accompanying unaudited consolidated financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended September 30, 2021, filed with the SEC.

Property and Equipment (Tables)

9 Months Ended

Jun. 30, 2022

Property, Plant and Equipment [Abstract]

Summary of Property and Equipment

The following table summarizes the Company’s major classes of property and equipment:


	June 30, 2022		September 30, 2021
	(In thousands)
Computers, software, office equipment and furniture	$	2,210	$	2,170
Research equipment	31,678		27,500
Leasehold improvements	42,017		41,524
Construction in Progress	22,338		345
Land	2,996		—
Total gross fixed assets	101,239		71,539
Less: Accumulated depreciation and amortization	(29,335)		(22,864)
Property and equipment, net	$	71,904	$	48,675

Investments (Tables)

9 Months Ended

Jun. 30, 2022

Investments, Debt and Equity Securities [Abstract]

Summary of Short-term and Long-term Investments and Marketable Securities

The following tables summarize the Company’s short-term and long-term investments and marketable securities as of June 30, 2022 and September 30, 2021 by measurement category:


	As of June 30, 2022
	(In thousands)
	Cost Basis		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value
Classified as Cash Equivalents
Commercial notes (due within ninety days)	$	25,325	$	11	$	—	$	25,336
Classified as Held to Maturity
Commercial notes (due within one year)	$	227,057	$	21	$	(1,588)	$	225,490
Commercial notes (due within one through three years)	$	165,920	$	—	$	(6,380)	$	159,540
Certificate of deposit (due within one year)	$	50,000	$	—	$	—	$	50,000
Classified as Marketable Securities
Marketable securities	$	—	$	—	$	—	$	—
Total	$	468,302	$	32	$	(7,968)	$	460,366

	As of September 30, 2021
	(In thousands)
	Cost Basis		Gross Unrealized Gains		Gross Unrealized Losses		Fair Value
Classified as Held to Maturity
Commercial notes (due within one year)	$	56,627	$	803	$	—	$	57,430
Commercial notes (due within one through three years)	$	195,595	$	1,151	$	(103)	$	196,643
Certificate of deposit (due within one through two years)	$	50,000	$	—	$	—	$	50,000
Classified as Marketable Securities
Marketable securities	$	127,481	$	—	$	(753)	$	126,728
Total	$	429,703	$	1,954	$	(856)	$	430,801

Intangible Assets (Tables)

9 Months Ended

Jun. 30, 2022

Goodwill and Intangible Assets Disclosure [Abstract]

Schedule of Intangible Assets

The following table provides details on the Company’s intangible asset balances:


	Intangible Assets Subject to Amortization
	(in thousands)
Balance at September 30, 2021	$	13,663
Impairment	—
Amortization	(1,276)
Balance at June 30, 2022	$	12,387

Leases (Tables)

9 Months Ended

Jun. 30, 2022

Leases [Abstract]

Summary of Maturities of Operating Lease Liabilities on an Undiscounted Basis

The following table presents payments of operating lease liabilities on an undiscounted basis as of June 30, 2022:


	(in thousands)
2022 (remainder of fiscal year)	$	1,309
2023	5,802
2024	8,094
2025	11,800
2026	12,313
2027 and thereafter	114,109
Total	$	153,427
Less imputed interest	$	(72,313)
Total operating lease liabilities (includes current portion)	$	81,114

Stock-Based Compensation (Tables)

9 Months Ended

Jun. 30, 2022

Share-Based Payment Arrangement [Abstract]

Summarized Information about Stock Options

The following table summarizes information about stock options:


	Number of Options Outstanding	Weighted- Average Exercise Price Per Share		Weighted- Average Remaining Contractual Term	Aggregate Intrinsic Value
Balance at September 30, 2021	3,456,239	$	19.60
Granted	—	—
Cancelled	(106,801)	43.68
Exercised	(506,596)	8.45
Balance at June 30, 2022	2,842,842	$	20.60	5.1 years	$	55,434,252
Exercisable at June 30, 2022	2,370,089	$	16.14	4.6 years	$	52,941,990

Assumptions Used to Value Stock Options

The assumptions used to value stock options are as follows:


	Nine Months Ended June 30,
	2022	2021
Dividend yield	N/A	—
Risk-free interest rate	N/A	0.4% - 1.1%
Volatility	N/A	86% - 90.4%
Expected life (in years)	N/A	6.25
Weighted average grant date fair value per share of options granted	N/A	$	48.64

Summary of Share Activity Related to RSUs

The following table summarizes the activity of the Company’s RSUs:


	Number of RSUs	Weighted- Average Grant Date Fair Value Per Share
Unvested at September 30, 2021	3,831,850	$	61.24
Granted	1,691,367	56.73
Vested	(962,188)	49.10
Forfeited	(95,625)	69.32
Unvested at June 30, 2022	4,465,404	$	61.97

Fair Value Measurements (Tables)

9 Months Ended

Jun. 30, 2022

Fair Value Disclosures [Abstract]

Fair Value Measurements for Assets and Liabilities Measured at Fair Value on Recurring Basis

The following table summarizes fair value measurements at June 30, 2022 and September 30, 2021 for assets and liabilities measured at fair value on a recurring basis:

June 30, 2022:


	Level 1		Level 2		Level 3		Total
	(in thousands)
Classified as Cash and cash equivalents
Commercial Notes	$	—	$	25,336	$	—	$	25,336
Classified as Marketable Securities
Marketable securities	$	—	$	—	$	—	$	—
Classified as Held to Maturity
Short-term investments	$	—	$	225,490	$	—	$	225,490
Long-term investments	$	—	$	159,540	$	—	$	159,540
Certificate of deposits	$	50,000	$	—	$	—	$	50,000
Classified as Contingent Consideration
Contingent consideration	$	—	$	—	$	—	$	—

September 30, 2021:


	Level 1		Level 2		Level 3		Total
	(in thousands)
Classified as Marketable Securities
Marketable securities	$	126,728	$	—	$	—	$	126,728
Classified as Held to Maturity
Short-term investments	$	—	$	57,430	$	—	$	57,430
Long-term investments	$	—	$	196,643	$	—	$	196,643
Certificate of deposit	$	50,000	$	—	$	—	$	50,000
Classified as Contingent Consideration
Contingent consideration	$	—	$	—	$	—	$	—

Organization and Significant Accounting Policies - Additional Information (Detail) ft² in Thousands, $ in Thousands		9 Months Ended
	Dec. 20, 2021 ft² a	Jun. 30, 2022 USD ($) ft² a	Nov. 19, 2021 ft²	Sep. 30, 2021 USD ($)
Organization And Significant Accounting Policies [Line Items]
Tax increment financing award		$ 16,000
State income tax credits		2,500
Cash and cash equivalents		139,439		$ 184,434
Restricted cash		7,400
Short term investments		277,057		56,627
Marketable securities		0		126,728
Long term investments		165,920		$ 245,595
Decrease in cash and investments		31,000
GSK
Organization And Significant Accounting Policies [Line Items]
Upfront milestone payment received		120,000
Janssen
Organization And Significant Accounting Policies [Line Items]
Development regulatory and sales milestones payments		4,900,000
Variable Interest Entity, Primary Beneficiary \| Visirna Therapeutics, Inc.
Organization And Significant Accounting Policies [Line Items]
Cash and cash equivalents		$ 60,000
Wisconsin \| Verona Technology Park
Organization And Significant Accounting Policies [Line Items]
Land purchased, number of acres \| a	13	13
Wisconsin \| Drug Manufacturing Facility
Organization And Significant Accounting Policies [Line Items]
Planned area of the site (in sq ft) \| ft²	160	160
Wisconsin \| Laboratory and Office Facility
Organization And Significant Accounting Policies [Line Items]
Planned area of the site (in sq ft) \| ft²	140	140
California \| Research Facility in San Diego
Organization And Significant Accounting Policies [Line Items]
Office space leases (in sq ft) \| ft²		144	144

Collaboration and License Agreements - Amgen, Inc - Additional Information (Detail) $ in Thousands		3 Months Ended		9 Months Ended
	Sep. 28, 2016 USD ($) agreement	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Sep. 30, 2021 USD ($)	Jul. 31, 2020 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues		$ 32,412	$ 45,891	$ 211,656	$ 100,004
Contract liabilities		84,288		84,288		$ 111,055
Collaboration and License agreements \| Amgen
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Number of agreements \| agreement	2
Cash received as due under collaboration agreement	$ 35,000
License Collaboration And Stock Purchase Agreement \| Amgen
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Proceeds from the issuance of common stock	21,500
Olpasiran and ARO-AMG1 Agreement \| Amgen
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Milestone payments	$ 30,000						$ 20,000
Revenues		0	$ 0	0	$ 0
Contract liabilities		0		0
Contract assets		0		0
Olpasiran Agreement \| Amgen \| Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Additional remaining development regulatory and sales milestones payments		$ 400,000		$ 400,000

Collaboration and License Agreements - Janssen Pharmaceuticals, Inc - Additional Information (Detail)		3 Months Ended		9 Months Ended
	Oct. 03, 2018 USD ($) obligation	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Sep. 30, 2021 USD ($)	May 31, 2021 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues		$ 32,412,000	$ 45,891,000	$ 211,656,000	$ 100,004,000
Deferred revenue		84,288,000		84,288,000		$ 111,055,000
Collaboration and License agreements
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Initial transaction price	$ 252,700,000
JJDC \| Common Stock Purchase Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Proceeds from the issuance of common stock	75,000,000
Janssen \| Collaboration and License agreements
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Cash received as due under collaboration agreement	175,000,000
Janssen
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Milestone payment	73,000,000
Development, regulatory and sales milestones payments		4,900,000,000		4,900,000,000
Janssen \| License Agreement \| Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development, regulatory and sales milestones payments	1,600,000,000
Janssen \| Collaboration Agreement \| Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development, regulatory and sales milestones payments	600,000,000
Janssen \| JNJ-3989 (ARO-HBV) Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Milestone payment	$ 25,000,000
Number of distinct performance obligations \| obligation	1
Revenues		0	0	0	20,200,000
Contract assets		0		0
Deferred revenue		0		0
Janssen \| JNJ-75220795 (ARO-JNJ1)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Milestone payment			10,000,000		10,000,000		$ 10,000,000
Revenues		0	$ 200,000	100,000	$ 500,000
Contract assets		0		0
Deferred revenue		$ 0		$ 0

Collaboration and License Agreements - Takeda Pharmaceuticals U.S.A., Inc - Additional Information (Detail) $ in Thousands		3 Months Ended		9 Months Ended
	Oct. 07, 2020 USD ($) obligation bundle	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Sep. 30, 2021 USD ($)	Jan. 31, 2021 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues		$ 32,412	$ 45,891	$ 211,656	$ 100,004
Deferred revenue		84,288		84,288		$ 111,055
Deferred revenue, net of current portion		71,162		71,162		$ 131,495
Takeda License Agreement \| License and Co-Funding Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Cash received as due under collaboration agreement							$ 300,000
Number of distinct performance obligations \| obligation	1
Number of distinct bundle \| bundle	1
Initial transaction price	$ 300,000
Revenues		25,500	$ 35,700	67,100	$ 69,300
Contract assets		0		0
Takeda License Agreement \| License and Co-Funding Agreement \| Deferred Revenue
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Deferred revenue		71,000		71,000
Deferred revenue, net of current portion		71,200		71,200
Takeda License Agreement \| License and Co-Funding Agreement \| Accrued Expenses
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Deferred revenue		$ 7,800		$ 7,800
Takeda License Agreement \| License and Co-Funding Agreement \| Minimum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Percentage of eligible to receive tiered royalties on net sales	20.00%
Takeda License Agreement \| License and Co-Funding Agreement \| Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Percentage of eligible to receive tiered royalties on net sales	25.00%
Development regulatory and sales milestones payments							$ 740,000

Collaboration and License Agreements - Horizon Therapeutics Ireland DAC - Additional Information (Detail) $ in Thousands		3 Months Ended		9 Months Ended
	Jun. 18, 2021 USD ($) obligation bundle	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Sep. 30, 2021 USD ($)	Jul. 31, 2021 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues		$ 32,412	$ 45,891	$ 211,656	$ 100,004
Contract liabilities		84,288		84,288		$ 111,055
Horizon Therapeutics Ireland DAC \| ARO-XDH
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Cash received as due under collaboration agreement							$ 40,000
Number of distinct performance obligations \| obligation	1
Initial transaction price	$ 40,000
Revenues		6,700	$ 0	20,000	0
Contract assets		0		0
Contract liabilities		13,300		13,300
Horizon Therapeutics Ireland DAC \| License Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Number of distinct bundle \| bundle	1
Number of distinct performance obligations \| obligation	1
Horizon Therapeutics Ireland DAC \| ARO-XDH Supply Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues				1,300	$ 0
Contract assets		0		0
Contract liabilities		$ 0		$ 0
Horizon Therapeutics Ireland DAC \| Maximum \| ARO-XDH
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development regulatory and sales milestones payments							$ 660,000

Collaboration and License Agreements - Glaxosmithkline Intellectual Property (No. 3) Limited - Additional Information (Detail) $ in Thousands			1 Months Ended	3 Months Ended		9 Months Ended
	Nov. 22, 2021 USD ($) obligation bundle	Oct. 03, 2018 USD ($)	Jan. 31, 2022 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($)	Jun. 30, 2021 USD ($)	Sep. 30, 2021 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues				$ 32,412	$ 45,891	$ 211,656	$ 100,004
Contract liabilities				84,288		84,288		$ 111,055
Collaboration and License agreements
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Initial transaction price		$ 252,700
GSK \| Collaboration and License agreements
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Milestone payment	$ 120,000
Milestone payment receivable at start of phase two	30,000
Milestone payment receivable upon achievement of phase two and first patient dosed in phase three	100,000
GSK \| Collaboration and License agreements \| Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Commercial milestone payments at first commercial sale	190,000
Sales-related milestone payments	$ 590,000
GSK \| ARO-HSD Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Number of distinct performance obligations \| obligation	1
Number of distinct bundle \| bundle	1
Initial transaction price	$ 120,000
Cash received as due under collaboration agreement			$ 120,000
Performance obligation related to agreement, upfront payment				120,000		120,000
Revenues						120,000	$ 0
Contract assets				0		0
Contract liabilities				$ 0		$ 0

Collaboration and License Agreements - Joint Venture and License Agreement with Visirna Therapeutics, Inc. - Additional Information (Detail) (Details) - USD ($) $ in Thousands		9 Months Ended
	Apr. 25, 2022	Jun. 30, 2022	Jun. 30, 2021
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Proceeds from investment in joint venture		$ 60,000	$ 0
Visirna Therapeutics, Inc. \| Variable Interest Entity, Primary Beneficiary
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Proceeds from investment in joint venture	$ 60,000

Property and Equipment - Summary of Property and Equipment (Detail) - USD ($) $ in Thousands	Jun. 30, 2022	Sep. 30, 2021
Property, Plant and Equipment [Abstract]
Computers, software, office equipment and furniture	$ 2,210	$ 2,170
Research equipment	31,678	27,500
Leasehold improvements	42,017	41,524
Construction in Progress	22,338	345
Land	2,996	0
Total gross fixed assets	101,239	71,539
Less: Accumulated depreciation and amortization	(29,335)	(22,864)
Property and equipment, net	$ 71,904	$ 48,675

Property and Equipment - Additional Information (Detail) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Property, Plant and Equipment [Abstract]
Depreciation and amortization expense for property and equipment	$ 2.2	$ 1.6	$ 6.5	$ 4.5

Investments - Summary of Short-term and Long-term Investments and Marketable Securities (Detail) - USD ($) $ in Thousands	1 Months Ended
	Apr. 30, 2022	Jun. 30, 2022	Sep. 30, 2021
Schedule Of Held To Maturity Securities And Marketable Securities [Line Items]
Equity securities sold	$ 122,300
Total, Cost Basis		$ 468,302	$ 429,703
Total, Gross Unrealized Gains		32	1,954
Total, Gross Unrealized Losses		(7,968)	(856)
Total, Fair Value		460,366	430,801
Commercial notes (due within one year)
Schedule Of Held To Maturity Securities And Marketable Securities [Line Items]
Held to Maturity, Cost Basis		227,057	56,627
Held to Maturity, Gross Unrealized Gains		21	803
Held to Maturity, Gross Unrealized Losses		(1,588)	0
Held to Maturity, Fair Value		225,490	57,430
Commercial notes (due within one through three years)
Schedule Of Held To Maturity Securities And Marketable Securities [Line Items]
Held to Maturity, Cost Basis		165,920	195,595
Held to Maturity, Gross Unrealized Gains		0	1,151
Held to Maturity, Gross Unrealized Losses		(6,380)	(103)
Held to Maturity, Fair Value		159,540	196,643
Certificate of deposit (due within one through two years)
Schedule Of Held To Maturity Securities And Marketable Securities [Line Items]
Held to Maturity, Cost Basis			50,000
Held to Maturity, Gross Unrealized Gains			0
Held to Maturity, Gross Unrealized Losses			0
Held to Maturity, Fair Value			50,000
Certificate of deposit (due within one year)
Schedule Of Held To Maturity Securities And Marketable Securities [Line Items]
Held to Maturity, Cost Basis		50,000
Held to Maturity, Gross Unrealized Gains		0
Held to Maturity, Gross Unrealized Losses		0
Held to Maturity, Fair Value		50,000
Marketable securities
Schedule Of Held To Maturity Securities And Marketable Securities [Line Items]
Marketable Securities, Cost Basis		0	127,481
Marketable Securities, Gross Unrealized Gains		0	0
Marketable Securities, Gross Unrealized Losses		0	(753)
Marketable Securities, Fair Value		0	$ 126,728
Commercial notes (due within ninety days)
Schedule Of Held To Maturity Securities And Marketable Securities [Line Items]
Cash Equivalents, Cost Basis		25,325
Cash Equivalents, Gross Unrealized Gains		11
Cash Equivalents, Gross Unrealized Losses		0
Cash Equivalents, Fair Value		$ 25,336

Intangible Assets - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Finite Lived Intangible Assets [Line Items]
Amortization expense	$ 400	$ 400	$ 1,276	$ 1,300
Amortization of license agreements remainder of fiscal year 2022	400		400
Amortization of license agreements in 2023	1,700		1,700
Amortization of license agreements in 2024	1,700		1,700
Amortization of license agreements in 2025	1,700		1,700
Amortization of license agreements in 2026	1,700		1,700
Amortization of license agreements, thereafter	5,200		$ 5,200
Novartis \| Licensing Agreement
Finite Lived Intangible Assets [Line Items]
Amortization period of intangible assets			21 years
Finite-lived intangible assets, accumulated amortization	1,100		$ 1,100
Novartis \| Patents
Finite Lived Intangible Assets [Line Items]
Amortization period of intangible assets			14 years
Finite-lived intangible assets, accumulated amortization	$ 11,400		$ 11,400

Intangible Assets - Schedule of Intangible Assets (Detail) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Finite-Lived Intangible Assets [Roll Forward]
Intangible assets subject to amortization, beginning balance			$ 13,663
Impairment			0
Amortization	$ (400)	$ (400)	(1,276)	$ (1,300)
Intangible assets subject to amortization, ending balance	$ 12,387		$ 12,387

Stockholders' Equity - Additional Information (Detail) - USD ($)	1 Months Ended
	Aug. 31, 2020	Jun. 30, 2022	Sep. 30, 2021
Class Of Stock [Line Items]
Capital stock authorized for issuance (in shares)		150,000,000
Common stock, shares authorized (in shares)		145,000,000	145,000,000
Common stock, par value (in dollars per share)		$ 0.001	$ 0.001
Preferred stock, shares authorized (in shares)		5,000,000
Preferred stock, par value (in dollars per share)		$ 0.001
Common stock, shares outstanding (in shares)		105,795,456	104,327,000
At The Market Agreement
Class Of Stock [Line Items]
Shares issued to institutional investors (in shares)		0
At The Market Agreement \| Maximum
Class Of Stock [Line Items]
Common stock shares value reserved for future issuance (in shares)	$ 250,000,000
Percentage of commission to sales agent	3.00%
2004 Equity Incentive Plan, 2013 Equity Incentive Plan, 2021 Equity Incentive Plan and Inducement Grants
Class Of Stock [Line Items]
Common Stock, Share reserve for issuance (in shares)		13,942,716

Commitments and Contingencies - Additional Information (Detail) ft² in Thousands		3 Months Ended		9 Months Ended
	Dec. 20, 2021 USD ($) ft² a	Jun. 30, 2022 USD ($) ft²	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($) ft² a	Jun. 30, 2021 USD ($)
Other Commitments [Line Items]
Contingent liabilities		$ 0		$ 0
Technology License Commitments
Other Commitments [Line Items]
Milestone payments		$ 0	$ 0	$ 0	$ 0
Verona Technology Park \| Wisconsin
Other Commitments [Line Items]
Land purchased, number of acres \| a	13			13
Drug Manufacturing Facility \| Wisconsin
Other Commitments [Line Items]
Planned area of the site (in sq ft) \| ft²	160	160		160
Laboratory and Office Facility \| Wisconsin
Other Commitments [Line Items]
Planned area of the site (in sq ft) \| ft²	140	140		140
Facilities \| Minimum
Other Commitments [Line Items]
Amount intends to invest for buildout of the facilities	$ 200,000,000
Facilities \| Maximum
Other Commitments [Line Items]
Amount intends to invest for buildout of the facilities	$ 250,000,000

Leases - Additional Information (Detail)			1 Months Ended	2 Months Ended	3 Months Ended		9 Months Ended		17 Months Ended
Leases - Additional Information (Detail)	Nov. 19, 2021 USD ($) ft² Option	Oct. 23, 2020 USD ($) ft²	Apr. 30, 2019 USD ($) ft² Option	Dec. 31, 2020 USD ($) ft²	Jun. 30, 2022 USD ($) ft²	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($) ft²	Jun. 30, 2021 USD ($)	May 31, 2020 USD ($) ft²	Mar. 31, 2020 USD ($) ft²	Jan. 31, 2016 ft² Option
Lessee Lease Description [Line Items]
Estimated lease payments					$ 153,427,000		$ 153,427,000
Operating lease cost					3,400,000	$ 1,600,000	6,000,000	$ 3,600,000
Variable lease cost					200,000	100,000	500,000	600,000
Short-term lease cost					$ 0	$ 0	0	0
Operating lease cash payments							$ 3,400,000	$ 2,200,000
Weighted-average remaining lease term					7 years 3 months 18 days		7 years 3 months 18 days
Weighted-average discount rate					8.50%		8.50%
Halozyme, Inc. \| California \| Sublease Agreement
Lessee Lease Description [Line Items]
Office space leases (in sq ft) \| ft²										21,000
Estimated lease payments										$ 2,000,000
Corporate Headquarters In Pasadena \| California
Lessee Lease Description [Line Items]
Office space leases (in sq ft) \| ft²		24,000
Estimated lease payments		$ 6,900,000
Payments for leasehold improvements, net of tenant improvement allowances		$ 4,000,000
Corporate Headquarters In Pasadena \| Colorado Owner, LLC \| California
Lessee Lease Description [Line Items]
Lease term			91 months
Office space leases (in sq ft) \| ft²			24,000
Estimated lease payments			$ 8,700,000
Payments for leasehold improvements, net of tenant improvement allowances			$ 3,500,000
Number of options to renew \| Option			1
Operating lease renewal term			5 years
Research Facility in Madison \| Wisconsin
Lessee Lease Description [Line Items]
Office space leases (in sq ft) \| ft²											60,000
Estimated lease payments				$ 1,200,000					$ 26,200,000
Number of options to renew \| Option											2
Operating lease renewal term											5 years
Additional office space for lease \| ft²				10,743					40,000
Expected leasehold improvements, net of tenant improvement allowances									$ 11,000,000
Research Facility in San Diego \| California
Lessee Lease Description [Line Items]
Lease term	15 years
Office space leases (in sq ft) \| ft²	144,000				144,000		144,000
Estimated lease payments	$ 119,000,000
Payments for leasehold improvements, net of tenant improvement allowances	$ 31,000,000
Operating lease renewal term	10 years
Estimated payments for operating expenses	$ 3,000,000
Research Facility in San Diego \| California \| Maximum
Lessee Lease Description [Line Items]
Number of options to renew \| Option	1

Leases - Summary of Maturities of Operating Lease Liabilities on an Undiscounted Basis (Detail) $ in Thousands	Jun. 30, 2022 USD ($)
Leases [Abstract]
2022 (remainder of fiscal year)	$ 1,309
2023	5,802
2024	8,094
2025	11,800
2026	12,313
2027 and thereafter	114,109
Total	153,427
Less imputed interest	(72,313)
Total operating lease liabilities (includes current portion)	$ 81,114

Stock-Based Compensation - Additional Information (Detail) - USD ($) $ in Millions	3 Months Ended		9 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021	Sep. 30, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of options outstanding (in shares)	2,842,842		2,842,842		3,456,239
Dividend yield				0.00%
Employee Stock Option
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense	$ 2.6	$ 3.2	$ 8.3	$ 9.6
Grant date fair value of the options granted	0.0	0.9	0.0	9.0
Intrinsic value of options exercised	1.6	10.2	24.9	63.0
Unrecognized pre-tax compensation expense	14.9		$ 14.9
Weighted average period to recognize pre-tax compensation expense			1 year 8 months 12 days
Dividend yield			0.00%
Restricted Stock Units (RSUs)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation expense	$ 33.7	15.4	$ 83.4	32.5
Weighted average period to recognize pre-tax compensation expense	2 years 8 months 12 days
Grant date fair value of other than options granted	$ 42.5	$ 3.1	95.2	$ 112.1
Unrecognized pre-tax compensation expense	$ 190.3		$ 190.3
2004 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares reserve for issuance (in shares)	216,607		216,607
2004 Equity Incentive Plan \| Employee Stock Option
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of options outstanding (in shares)	216,607		216,607
2013 Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares reserve for issuance (in shares)	4,114,999		4,114,999
Number of shares forfeited (in shares)			119,612
2013 Incentive Plan \| Employee Stock Option
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of options outstanding (in shares)	1,806,987		1,806,987
2013 Incentive Plan \| Restricted Stock Units (RSUs)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of restricted stock units outstanding (in shares)	2,308,012		2,308,012
Outside Of Equity Compensation Plans
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares reserve for issuance (in shares)	816,248		816,248
Outside Of Equity Compensation Plans \| Restricted Stock Units (RSUs)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares reserve for issuance (in shares)	682,500		682,500
2021 Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common Stock, Share reserve for issuance (in shares)	6,627,845		6,627,845
2021 Incentive Plan \| Employee Stock Option
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of options outstanding (in shares)	3,000		3,000
2021 Incentive Plan \| Restricted Stock Units (RSUs)
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of restricted stock units outstanding (in shares)	1,507,267		1,507,267

Stock-Based Compensation - Summarize Information about Stock Options (Detail) - USD ($)	9 Months Ended
	Jun. 30, 2022
Number of Options Outstanding
Beginning balance (in shares)	3,456,239
Granted (in shares)	0
Cancelled (in shares)	(106,801)
Exercised (in shares)	(506,596)
Ending balance (in shares)	2,842,842
Number of Options Outstanding, Exercisable (in shares)	2,370,089
Weighted- Average Exercise Price Per Share
Beginning balance (in dollars per share)	$ 19.60
Granted (in dollars per share)	0
Cancelled (in dollars per share)	43.68
Exercised (in dollars per share)	8.45
Ending balance (in dollars per share)	20.60
Weighted-Average Exercise Price Per Share, Exercisable (in dollars per share)	$ 16.14
Weighted- Average Remaining Contractual Term	5 years 1 month 6 days
Weighted-Average Remaining Contractual Term, Exercisable	4 years 7 months 6 days
Aggregate Intrinsic Value	$ 55,434,252
Aggregate Intrinsic Value, Exercisable	$ 52,941,990

Stock-Based Compensation - Assumptions Used to Value Stock Options (Detail)	9 Months Ended
	Jun. 30, 2021 $ / shares
Share-Based Payment Arrangement [Abstract]
Dividend yield	0.00%
Risk-free interest rate, minimum	0.40%
Risk-free interest rate, maximum	1.10%
Volatility, minimum	86.00%
Volatility, maximum	90.40%
Expected life (in years)	6 years 3 months
Weighted average grant date fair value per share of options granted	$ 48.64

Stock-Based Compensation - Summary of RSUs Activity (Detail) - Restricted Stock Units (RSUs)	9 Months Ended
	Jun. 30, 2022 $ / shares shares
Number of RSUs
Beginning of period (in shares) \| shares	3,831,850
Granted (in shares) \| shares	1,691,367
Vested (in shares) \| shares	(962,188)
Forfeited (in shares) \| shares	(95,625)
End of period (in shares) \| shares	4,465,404
Weighted- Average Grant Date Fair Value Per Share
Beginning balance (in dollars per share) \| $ / shares	$ 61.24
Granted (in dollars per share) \| $ / shares	56.73
Vested (in dollars per share) \| $ / shares	49.10
Forfeited (in dollars per share) \| $ / shares	69.32
Ending balance (in dollars per share) \| $ / shares	$ 61.97

Fair Value Measurements - Fair Value Measurements for Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail) - Fair Value, Measurements, Recurring - USD ($) $ in Thousands	Jun. 30, 2022	Sep. 30, 2021
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Commercial Notes	$ 25,336
Marketable securities	0	$ 126,728
Short-term investments	225,490	57,430
Long-term investments	159,540	196,643
Certificate of deposits	50,000	50,000
Contingent consideration	0	0
Level 1
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Commercial Notes	0
Marketable securities	0	126,728
Short-term investments	0	0
Long-term investments	0	0
Certificate of deposits	50,000	50,000
Contingent consideration	0	0
Level 2
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Commercial Notes	25,336
Marketable securities	0	0
Short-term investments	225,490	57,430
Long-term investments	159,540	196,643
Certificate of deposits	0	0
Contingent consideration	0	0
Level 3
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Commercial Notes	0
Marketable securities	0	0
Short-term investments	0	0
Long-term investments	0	0
Certificate of deposits	0	0
Contingent consideration	$ 0	$ 0