Arrowhead Announces JNJ-75220795 in Development for NASH
JNJ-75220795 is an investigational siRNA therapeutic developed using Arrowhead’s proprietary TRIMTM platform and designed to reduce expression in the liver of patatin like phospholipase domain containing 3 (PNPLA3) as a potential treatment for patients with non-alcoholic steatohepatitis (NASH). PNPLA3 has strong genetic and preclinical validation as a driver of fat accumulation and damage in the livers of patients who carry the common I148M mutation.
Arrowhead entered into a research collaboration and option agreement with Janssen in
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