Arrowhead Presents ARC-520 and ARC-521 Clinical Data at The International Liver Congress™
Together, these presentations demonstrate that in human clinical studies, RNAi interference (RNAi) as a mechanism can rapidly and significantly reduce HBV viral antigens. In addition, RNAi appears to synergize with current standard-of-care nucleotide and nucleoside analogues (NUCs) to rapidly lower serum levels of HBV DNA. Arrowhead is currently developing ARO-HBV, a follow-on product candidate that utilizes the company's next generation, proprietary subcutaneously administered delivery vehicle, as a potentially curative therapy for patients with chronic hepatitis B infection.
Presentation materials can be accessed by visiting the Events section of the Arrowhead website. Additional details including abstracts can be found on the ILC website at https://ilc-congress.eu/ by searching for the following:
Prolonged RNA interference therapy with ARC-520 Injection in treatment naïve, HBeAg positive and negative patients with chronic HBV results in significant reductions of HBs antigen
- Presentation Reference: PS-045
- Session: Parallel session: Hepatitis B and D: Emerging treatment options
Date and Time:
April 20, 2017at 5:30 PM CET
Man-Fung Yuen, et al.
A phase 1 study to evaluate safety and tolerability of escalating single doses of the HBV RNA interference drug ARC-521 in a healthy volunteer population
- Presentation Reference: THU-176
- Session: Viral hepatitis: Hepatitis B and D - Clinical (therapy, new compounds, resistance)
Session Date and Time:
April 20, 2017from 8:00 AM to 6:00 PM CET
Edward Gane, et al.
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